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KMID : 1035620170050050239
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Allergy Asthma & Respiratory Disease
2017 Volume.5 No. 5 p.239 ~ p.247
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KAAACI Standardization Committee Report on the procedures and applications of the diagnostic tests for drug allergy
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Yang Min-Suk
Ban Ga-Young
Kim Min-Hye
Lim Kyung-Hwan
Kwon Hyouk-Soo
Song Woo-Jung
Jung Jae-Woo
Lee Jeong-Min
Suh Dong-In
Kwon Jae-Woo
Kim Se-Hoon
Shin Yoo-Seob
Kang Hye-Ryun
Kim Tae-Bum
Lee Byung-Jae
Lee Ai-Young
Park Hae-Sim
Cho Sang-Heon
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Abstract
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Diagnostic methods for drug allergy include the patient's history, in vivo skin test, in vitro laboratory test, and provocation test. However, the history is often not reliable, procedures for in vivo and in vitro tests are not standardized, and provocation tests are sometimes harmful to patients. Generally, skin prick and intradermal tests are useful for immediate reactions; in contrast, patch test and delayed reading of both skin prick and intradermal tests are helpful for delayed reactions. A drug provocation test is the gold standard for both responses, and it is necessary to be aware of exact indications and contraindications with appropriate drugs, doses, and intervals. To date, several methods have been developed to detect culprit agents for drug hypersensitivity reactions, but they are neither completely well validated nor standardized. Based on this awareness and necessity, the Korean Academy of Asthma, Allergy and Clinical Immunology launched the Standardization Committee to review the international guidelines and the literature, and then developed the consensus report on the procedures and applications of diagnostic tests for drug allergy.
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KEYWORD
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Drug hypersensitivity, Skin tests, Intradermal tests, Patch tests
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